| League Leaders Top 5 | |||||||
| Quarter Backs | Team | RTG | YDS | TDS | COMP | ATT | INTS |
| Drew Brees | New Orleans | 139.6 | 223 | 3 | 21 | 27 | 0 |
| Eli Manning | New York Giants | 106.3 | 346 | 5 | 34 | 53 | 1 |
| Peyton Manning | Indianapolis | 100.8 | 677 | 4 | 54 | 75 | 3 |
| Carson Palmer | Cincinnati | 99.4 | 482 | 5 | 43 | 66 | 2 |
| Marc Bulger (T-5) | St.Louis | 96.8 | 655 | 6 | 49 | 71 | 5 |
| Philip Rivers (T-5) | San Diego | 96.8 | 565 | 4 | 51 | 75 | 2 |
| Jon Sommons (T-5) | Houston | 96.8 | 653 | 5 | 35 | 64 | 3 |
| Running Backs | Team | YDS | TDS | ATT | AVG | ||
| Ahman Green | Houston | 312 | 2 | 74 | 4.2 | ||
| Willis McGahee | Baltimore | 287 | 2 | 77 | 3.7 | ||
| Shaun Alexander | Seattle | 281 | 3 | 56 | 5.0 | ||
| Ladainian Tomlinson | San Diego | 275 | 2 | 52 | 5.2 | ||
| Larry Johnson | Kansas City | 269 | 0 | 63 | 4.2 | ||
| Receiving | Team | REC | YDS | TDS | AVG | ||
| Chad Johnson (WR) | Cincinnati | 22 | 290 | 4 | 13.1 | ||
| Owen Daniels (TE) | Houston | 18 | 299 | 4 | 16.6 | ||
| Andre Johnson (WR) | Houston | 16 | 361 | 1 | 22.5 | ||
| Randy McMicheal (TE) | St.Louis | 15 | 118 | 1 | 7.8 | ||
| Jason Witten (TE) | Dallas | 14 | 99 | 0 | 7.0 |